학술논문
Evolution of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis
Document Type
article
Author
Judit Vidal-González; Javier Martínez; Akhilesh Mulay; Marta López; Anna Baiges; Ahmed Elmahdy; Katharina Lampichler; Geert Maleux; Johannes Chang; Marta Poncela; Gavin Low; Gabriele Ghigliazza; Alexander Zipprich; Carmen Picón; Rushabh Shah; Elba Llop; Anna Darnell; Martin H. Maurer; Lawrence Bonne; Enrique Ramón; Sergi Quiroga; Juan G. Abraldes; Aleksander Krag; Jonel Trebicka; Cristina Ripoll; Vincenzo La Mura; Puneeta Tandon; Rita García-Martínez; Michael Praktiknjo; Wim Laleman; Thomas Reiberger; Annalisa Berzigotti; Virginia Hernández-Gea; José Luis Calleja; Emmanuel A. Tsochatzis; Agustín Albillos; Macarena Simón-Talero; Joan Genescà
Source
JHEP Reports, Vol 6, Iss 2, Pp 100977- (2024)
Subject
Language
English
ISSN
2589-5559
Abstract
Background & Aims: Spontaneous portosystemic shunts (SPSS) develop frequently in cirrhosis. Changes over time and the effect of aetiological interventions on SPSS are unknown, so we aimed to explore the effect of these variables on SPSS evolution. Methods: Patients with cirrhosis from the Baveno VI-SPSS cohort were selected provided a follow-up abdominal CT or MRI scan was available. Clinical and laboratory data were collected at baseline and follow-up. Imaging tests were reviewed to evaluate changes in the presence and size of SPSS (large (L)-SPSS was ≥8 mm) over time. Regarding alcohol- or HCV-related cirrhosis, two populations were defined: cured patients (abstinent from alcohol or successful HCV therapy), and non-cured patients. Results: A total of 617 patients were included. At baseline SPSS distribution was 22% L-SPSS, 30% small (S)-SPSS, and 48% without (W)-SPSS. During follow-up (median follow-up of 63 months), SPSS distribution worsened: L-SPSS 26%, S-SPSS 32%, and W-SPSS 42% (p