학술논문
Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
Document Type
article
Author
José M. Ruiz-Giardin; Marta Rivilla; Nieves Mesa; Alejandro Morales; Luis Rivas; Aída Izquierdo; Almudena Escribá; Juan V. San Martín; David Bernal-Bello; Elena Madroñal; Ana I. Farfán; Marta Guerrero; Ruth Calderón; Miguel A. Duarte; Sara I. Piedrabuena; María Toledano-Macías; José Á. Satué; Jorge Marrero; Cristina L. de Ancos; Begoña Frutos; Rafael Cristóbal; Guillermo Soria; Ibone Ayala-Larrañaga; Lorena Carpintero; Miguel de Hita; Celia Lara; Álvaro R. Llerena; Virginia García; Raquel Jiménez; Vanesa García; Elena M. Saiz-Lou; Santiago Prieto; Natalia González-Pereira; Luis Antonio Lechuga; Jorge Tarancón; Sonia Gonzalo
Source
Viruses, Vol 14, Iss 10, p 2284 (2022)
Subject
Language
English
ISSN
1999-4915
Abstract
Objectives. This study aimed to compare the characteristics of fully and partially vaccinated or unvaccinated coronavirus disease 2019 (COVID-19) patients who were hospitalised in a population of 220,000 habitants. Methods: Retrospective, observational, and population studies were conducted on patients who were hospitalised due to COVID-19 from March to October 2021. We assessed the impact of vaccination and other risk factors through Cox multivariate analysis. Results: A total of 500 patients were hospitalised, among whom 77 (15.4%) were fully vaccinated, 86 (17.2%) were partially vaccinated, and 337 (67.4%) were unvaccinated. Fully vaccinated (FV) patients were older and had a higher Charlson index than those of partially vaccinated and unvaccinated patients (NFV). Bilateral pneumonia was more frequent among NFV (259/376 (68.9%)) than among FV patients (32/75 (42.7%)). The former had more intensive care unit admissions (63/423) than the latter (4/77); OR: 2.80; CI (1.07–9.47). Increasing age HZ: 1.1 (1.06–1.14)) and haematological disease at admission HZ: 2.99 (1.26–7.11)) were independent risk factors for higher mortality during the first 30 days of hospitalisation. The probability of an earlier discharge in the subgroup of 440 patients who did not die during the first 30 days of hospitalisation was related to age (older to younger: HZ: 0.98 (0.97–0.99)) and vaccination status. Conclusions: Among the patients hospitalised because of COVID-19, complete vaccination was associated with less severe forms of COVID-19, with an earlier discharge date. Age and haematological disease were related to a higher mortality rate during the first 30 days of hospitalisation.