학술논문
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Document Type
article
Author
Moritz Schütte; Thomas Risch; Nilofar Abdavi-Azar; Karsten Boehnke; Dirk Schumacher; Marlen Keil; Reha Yildiriman; Christine Jandrasits; Tatiana Borodina; Vyacheslav Amstislavskiy; Catherine L. Worth; Caroline Schweiger; Sandra Liebs; Martin Lange; Hans- Jörg Warnatz; Lee M. Butcher; James E. Barrett; Marc Sultan; Christoph Wierling; Nicole Golob-Schwarzl; Sigurd Lax; Stefan Uranitsch; Michael Becker; Yvonne Welte; Joseph Lewis Regan; Maxine Silvestrov; Inge Kehler; Alberto Fusi; Thomas Kessler; Ralf Herwig; Ulf Landegren; Dirk Wienke; Mats Nilsson; Juan A. Velasco; Pilar Garin-Chesa; Christoph Reinhard; Stephan Beck; Reinhold Schäfer; Christian R. A. Regenbrecht; David Henderson; Bodo Lange; Johannes Haybaeck; Ulrich Keilholz; Jens Hoffmann; Hans Lehrach; Marie-Laure Yaspo
Source
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response.