학술논문
Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics.