학술논문
Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesityResearch in context
Document Type
article
Author
Johanna C. Andersson-Assarsson; Rosanne C. van Deuren; Felipe M. Kristensson; Marloes Steehouwer; Kajsa Sjöholm; Per-Arne Svensson; Marc Pieterse; Christian Gilissen; Magdalena Taube; Peter Jacobson; Rosie Perkins; Han G. Brunner; Mihai G. Netea; Markku Peltonen; Björn Carlsson; Alexander Hoischen; Lena M.S. Carlsson
Source
EBioMedicine, Vol 92, Iss , Pp 104621- (2023)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: Haematopoietic clones caused by somatic mutations with ≥2% variant allele frequency (VAF) increase with age and are linked to risk of haematological malignancies and cardiovascular disease. Recent observations suggest that smaller clones (VAF