학술논문
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma
Document Type
article
Author
Ziad Bakouny; David A. Braun; Sachet A. Shukla; Wenting Pan; Xin Gao; Yue Hou; Abdallah Flaifel; Stephen Tang; Alice Bosma-Moody; Meng Xiao He; Natalie Vokes; Jackson Nyman; Wanling Xie; Amin H. Nassar; Sarah Abou Alaiwi; Ronan Flippot; Gabrielle Bouchard; John A. Steinharter; Pier Vitale Nuzzo; Miriam Ficial; Miriam Sant’Angelo; Juliet Forman; Jacob E. Berchuck; Shaan Dudani; Kevin Bi; Jihye Park; Sabrina Camp; Maura Sticco-Ivins; Laure Hirsch; Sylvan C. Baca; Megan Wind-Rotolo; Petra Ross-Macdonald; Maxine Sun; Gwo-Shu Mary Lee; Steven L. Chang; Xiao X. Wei; Bradley A. McGregor; Lauren C. Harshman; Giannicola Genovese; Leigh Ellis; Mark Pomerantz; Michelle S. Hirsch; Matthew L. Freedman; Michael B. Atkins; Catherine J. Wu; Thai H. Ho; W. Marston Linehan; David F. McDermott; Daniel Y. C. Heng; Srinivas R. Viswanathan; Sabina Signoretti; Eliezer M. Van Allen; Toni K. Choueiri
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Sarcomatoid and rhabdoid tumours are highly aggressive forms of renal cell carcinoma that are also responsive to immunotherapy. In this study, the authors perform a comprehensive molecular characterization of these tumours discovering an enrichment of specific alterations and an inflamed phenotype.