학술논문
Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
Document Type
article
Author
Paloma Cejas; Yingtian Xie; Alba Font-Tello; Klothilda Lim; Sudeepa Syamala; Xintao Qiu; Alok K. Tewari; Neel Shah; Holly M. Nguyen; Radhika A. Patel; Lisha Brown; Ilsa Coleman; Wenzel M. Hackeng; Lodewijk Brosens; Koen M. A. Dreijerink; Leigh Ellis; Sarah Abou Alaiwi; Ji-Heui Seo; Sylvan Baca; Himisha Beltran; Francesca Khani; Mark Pomerantz; Alessandra Dall’Agnese; Jett Crowdis; Eliezer M. Van Allen; Joaquim Bellmunt; Colm Morrisey; Peter S. Nelson; James DeCaprio; Anna Farago; Nicholas Dyson; Benjamin Drapkin; X. Shirley Liu; Matthew Freedman; Michael C. Haffner; Eva Corey; Myles Brown; Henry W. Long
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.