학술논문
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
Document Type
article
Author
Etsuro Nanishi; Marisa E. McGrath; Timothy R. O’Meara; Soumik Barman; Jingyou Yu; Huahua Wan; Carly A. Dillen; Manisha Menon; Hyuk-Soo Seo; Kijun Song; Andrew Z. Xu; Luke Sebastian; Byron Brook; Anna-Nicole Bosco; Francesco Borriello; Robert K. Ernst; Dan H. Barouch; Sirano Dhe-Paganon; Ofer Levy; Matthew B. Frieman; David J. Dowling
Source
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
A longitudinal study in mice reveals that a booster dose of mRNA vaccine BNT162b2 enhances humoral and cell-mediated responses and provides sterilizing immunity against Omicron-induced lung infection in aged animals.