학술논문
Blood miRNA levels associated with ADHD traits in children across six European birth cohorts
Document Type
article
Author
Lene B. Dypås; Nur Duale; Ann-Karin Olsen; Mariona Bustamante; Lea Maitre; Geòrgia Escaramis; Jordi Julvez; Sofia Aguilar-Lacasaña; Sandra Andrusaityte; Maribel Casas; Marina Vafeiadi; Regina Grazuleviciene; Barbara Heude; Johanna Lepeule; Jose Urquiza; John Wright; Tiffany C. Yang; Martine Vrijheid; Kristine B. Gützkow
Source
BMC Psychiatry, Vol 23, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
1471-244X
Abstract
Abstract Background Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and highly heritable neurodevelopmental disorder of major societal concern. Diagnosis can be challenging and there are large knowledge gaps regarding its etiology, though studies suggest an interplay of genetic and environmental factors involving epigenetic mechanisms. MicroRNAs (miRNAs) show promise as biomarkers of human pathology and novel therapies, and here we aimed to identify blood miRNAs associated with traits of ADHD as possible biomarker candidates and further explore their biological relevance. Methods Our study population consisted of 1126 children (aged 5–12 years, 46% female) from the Human Early Life Exposome study, a study spanning six ongoing population-based European birth cohorts. Expression profiles of miRNAs in whole blood samples were quantified by microarray and tested for association with ADHD-related measures of behavior and neuropsychological functions from questionnaires (Conner’s Rating Scale and Child Behavior Checklist) and computer-based tests (the N-back task and Attention Network Test). Results We identified 29 miRNAs significantly associated (false discovery rate