학술논문
Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project)
Document Type
article
Author
Mario Serradilla-Martín; Celia Villodre; Laia Falgueras-Verdaguer; Natalia Zambudio-Carroll; José T. Castell-Gómez; Juan L. Blas-Laina; Vicente Borrego-Estella; Carlos Domingo-del-Pozo; Gabriel García-Plaza; Francisco J. González-Rodríguez; Eva M. Montalvá-Orón; Ángel Moya-Herraiz; Sandra Paterna-López; Miguel A. Suárez-Muñoz; Maialen Alkorta-Zuloaga; Gerardo Blanco-Fernández; Enrique Dabán-Collado; Miguel A. Gómez-Bravo; José I. Miota-de-Llamas; Fernando Rotellar; Belinda Sánchez-Pérez; Santiago Sánchez-Cabús; David Pacheco-Sánchez; Juan C. Rodríguez-Sanjuan; María A. Varona-Bosque; Lucía Carrión-Álvarez; Sofía de la Serna-Esteban; Cristina Dopazo; Elena Martín-Pérez; David Martínez-Cecilia; María J. Castro-Santiago; Dimitri Dorcaratto; Marta L. Gutiérrez-Díaz; José M. Asencio-Pascual; Fernando Burdío-Pinilla; Roberto Carracedo-Iglesias; Alfredo Escartín-Arias; Benedetto Ielpo; Gonzalo Rodríguez-Laiz; Andrés Valdivieso-López; Emilio De-Vicente-López; Vicente Alonso-Orduña; José M. Ramia
Source
Cancers, Vol 16, Iss 9, p 1676 (2024)
Subject
Language
English
ISSN
2072-6694
Abstract
(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing