학술논문
Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes
Document Type
article
Author
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Predicting the effects of mutations in a species is a major challenge in genetics. Here, the authors investigate protein sequence landscapes using diverged E. coli sequences, to predict tolerated mutations and capture interactions between mutations.