학술논문
Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease
Document Type
article
Author
Francesca A. Ververs; Anouk L. M. Eikendal; Daniel Kofink; Roos Nuboer; Jos J. M. Westenberg; Gijs T. Hovenkamp; Jitske J.A. Kemps; Iris C. J. Coenen; Joëlle J. N. Daems; Laura R. Claus; Yillie Ju; Nico M. Wulffraat; Cornelis K. van der Ent; Claudia Monaco; Marianne Boes; Tim Leiner; Heynric B. Grotenhuis; Henk S. Schipper
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 14 (2022)
Subject
Language
English
ISSN
2047-9980
Abstract
Background Adolescents with chronic disease are often exposed to inflammatory, metabolic, and hemodynamic risk factors for early atherosclerosis. Since postmortem studies have shown that atherogenesis starts in the aorta, the CDACD (Cardiovascular Disease in Adolescents with Chronic Disease) study investigated preclinical aortic atherosclerosis in these adolescents. Methods and Results The cross‐sectional CDACD study enrolled 114 adolescents 12 to 18 years old with chronic disorders including juvenile idiopathic arthritis, cystic fibrosis, obesity, corrected coarctation of the aorta, and healthy controls with a corrected atrial septal defect. Cardiovascular magnetic resonance was used to assess aortic pulse wave velocity and aortic wall thickness, as established aortic measures of preclinical atherosclerosis. Cardiovascular magnetic resonance showed a higher aortic pulse wave velocity, which reflects aortic stiffness, and higher aortic wall thickness in all adolescent chronic disease groups, compared with controls (P