학술논문
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Document Type
article
Author
Cees J. Weeland; Selina Kasprzak; Niels T. de Joode; Yoshinari Abe; Pino Alonso; Stephanie H. Ameis; Alan Anticevic; Paul D. Arnold; Srinivas Balachander; Nerisa Banaj; Nuria Bargallo; Marcelo C. Batistuzzo; Francesco Benedetti; Jan C. Beucke; Irene Bollettini; Vilde Brecke; Silvia Brem; Carolina Cappi; Yuqi Cheng; Kang Ik K. Cho; Daniel L. C. Costa; Sara Dallaspezia; Damiaan Denys; Goi Khia Eng; Sónia Ferreira; Jamie D. Feusner; Martine Fontaine; Jean-Paul Fouche; Rachael G. Grazioplene; Patricia Gruner; Mengxin He; Yoshiyuki Hirano; Marcelo Q. Hoexter; Chaim Huyser; Hao Hu; Fern Jaspers-Fayer; Norbert Kathmann; Christian Kaufmann; Minah Kim; Kathrin Koch; Yoo Bin Kwak; Jun Soo Kwon; Luisa Lazaro; Chiang-shan R. Li; Christine Lochner; Rachel Marsh; Ignacio Martínez-Zalacaín; David Mataix-Cols; Jose M. Menchón; Luciano Minnuzi; Pedro Silva Moreira; Pedro Morgado; Akiko Nakagawa; Takashi Nakamae; Janardhanan C. Narayanaswamy; Erika L. Nurmi; Ana E. Ortiz; Jose C. Pariente; John Piacentini; Maria Picó-Pérez; Fabrizio Piras; Federica Piras; Christopher Pittenger; Y. C. Janardhan Reddy; Daniela Rodriguez-Manrique; Yuki Sakai; Eiji Shimizu; Venkataram Shivakumar; Helen Blair Simpson; Noam Soreni; Carles Soriano-Mas; Nuno Sousa; Gianfranco Spalletta; Emily R. Stern; Michael C. Stevens; S. Evelyn Stewart; Philip R. Szeszko; Jumpei Takahashi; Tais Tanamatis; Jinsong Tang; Anders Lillevik Thorsen; David Tolin; Ysbrand D. van der Werf; Hein van Marle; Guido A. van Wingen; Daniela Vecchio; G. Venkatasubramanian; Susanne Walitza; Jicai Wang; Zhen Wang; Anri Watanabe; Lidewij H. Wolters; Xiufeng Xu; Je-Yeon Yun; Qing Zhao; ENIGMA OCD Working Group; Tonya White; Paul M. Thompson; Dan J. Stein; Odile A. van den Heuvel; Chris Vriend
Source
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Subject
Language
English
ISSN
2158-3188
Abstract
Abstract Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered ( https://osf.io/73dvy ) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (