학술논문
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
Document Type
article
Author
Francesca D’Addio; Anna Maestroni; Emma Assi; Moufida Ben Nasr; Giovanni Amabile; Vera Usuelli; Cristian Loretelli; Federico Bertuzzi; Barbara Antonioli; Francesco Cardarelli; Basset El Essawy; Anna Solini; Ivan C. Gerling; Cristina Bianchi; Gabriella Becchi; Serena Mazzucchelli; Domenico Corradi; Gian Paolo Fadini; Diego Foschi; James F. Markmann; Emanuela Orsi; Jan Škrha; Maria Gabriella Camboni; Reza Abdi; A. M. James Shapiro; Franco Folli; Johnny Ludvigsson; Stefano Del Prato; Gianvincenzo Zuccotti; Paolo Fiorina
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes.