학술논문
The clinical and genomic epidemiology of seasonal human coronaviruses in congregate homeless shelter settings: A repeated cross-sectional study
Document Type
article
Author
Eric J. Chow; Amanda M. Casto; Julia H. Rogers; Pavitra Roychoudhury; Peter D. Han; Hong Xie; Margaret G. Mills; Tien V. Nguyen; Brian Pfau; Sarah N. Cox; Caitlin R. Wolf; James P. Hughes; Timothy M. Uyeki; Melissa A. Rolfes; Emily Mosites; M. Mia Shim; Jeffrey S. Duchin; Nancy Sugg; Lea A. Starita; Janet A. Englund; Helen Y. Chu
Source
The Lancet Regional Health. Americas, Vol 15, Iss , Pp 100348- (2022)
Subject
Language
English
ISSN
2667-193X
Abstract
Summary: Background: The circulation of respiratory viruses poses a significant health risk among those residing in congregate settings. Data are limited on seasonal human coronavirus (HCoV) infections in homeless shelter settings. Methods: We analysed data from a clinical trial and SARS-CoV-2 surveillance study at 23 homeless shelter sites in King County, Washington between October 2019-May 2021. Eligible participants were shelter residents aged ≥3 months with acute respiratory illness. We collected enrolment data and nasal samples for respiratory virus testing using multiplex RT-PCR platform including HCoV. Beginning April 1, 2020, eligibility expanded to shelter residents and staff regardless of symptoms. HCoV species was determined by RT-PCR with species-specific primers, OpenArray assay or genomic sequencing for samples with an OpenArray relative cycle threshold