학술논문
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
Document Type
article
Author
Gizem Günes Günsel; Thomas M. Conlon; Aicha Jeridi; Rinho Kim; Zeynep Ertüz; Niklas J. Lang; Meshal Ansari; Mariia Novikova; Dongsheng Jiang; Maximilian Strunz; Mariia Gaianova; Christine Hollauer; Christina Gabriel; Ilias Angelidis; Sebastian Doll; Jeanine C. Pestoni; Stephanie L. Edelmann; Marlene Sophia Kohlhepp; Adrien Guillot; Kevin Bassler; Hannelore P. Van Eeckhoutte; Özgecan Kayalar; Nur Konyalilar; Tamara Kanashova; Sophie Rodius; Carolina Ballester-López; Carlos M. Genes Robles; Natalia Smirnova; Markus Rehberg; Charu Agarwal; Ioanna Krikki; Benoit Piavaux; Stijn E. Verleden; Bart Vanaudenaerde; Melanie Königshoff; Gunnar Dittmar; Ken R. Bracke; Joachim L. Schultze; Henrik Watz; Oliver Eickelberg; Tobias Stoeger; Gerald Burgstaller; Frank Tacke; Vigo Heissmeyer; Yuval Rinkevich; Hasan Bayram; Herbert B. Schiller; Marcus Conrad; Robert Schneider; Ali Önder Yildirim
Source
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.