학술논문
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
Document Type
article
Author
Samya Van Coillie; Emily Van San; Ines Goetschalckx; Bartosz Wiernicki; Banibrata Mukhopadhyay; Wulf Tonnus; Sze Men Choi; Ria Roelandt; Catalina Dumitrascu; Ludwig Lamberts; Geert Dams; Wannes Weyts; Jelle Huysentruyt; Behrouz Hassannia; Irina Ingold; Suhas Lele; Evelyne Meyer; Maya Berg; Ruth Seurinck; Yvan Saeys; An Vermeulen; Alexander L. N. van Nuijs; Marcus Conrad; Andreas Linkermann; Mohan Rajapurkar; Peter Vandenabeele; Eric Hoste; Koen Augustyns; Tom Vanden Berghe
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Catalytic iron is associated with intensive care unit mortality and is known to cause free radical-mediated cellular toxicity. Here the authors show that a soluble ferrostatin-analogue (a ferroptosis inhibitor) protects mice from injury and death in experimental iron overload induced and genetic models of organ dysfunction, but not sepsis-induced multiorgan dysfunction.