학술논문
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
Document Type
article
Author
Hikari Tanaka; Kanoh Kondo; Kyota Fujita; Hidenori Homma; Kazuhiko Tagawa; Xiaocen Jin; Meihua Jin; Yuki Yoshioka; Sumire Takayama; Hitomi Masuda; Rie Tokuyama; Yukoh Nakazaki; Takashi Saito; Takaomi Saido; Shigeo Murayama; Teikichi Ikura; Nobutoshi Ito; Yu Yamamori; Kentaro Tomii; Marco E. Bianchi; Hitoshi Okazawa
Source
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Tanaka et al use phosphoproteome analysis of post-mortem Alzheimer’s Disease (AD) brains and identified abnormal phosphorylation of Ku70, which leads to DNA damage and transcriptional repression-induced atypical cell death. In a mouse model of AD, the authors show that Ku70 phosporylation is regulated by extracellular high mobility group box 1 protein, thus shedding light on the mechanism of DNA damage in AD.