학술논문
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
PD-L1, the ligand for T-cell inhibitory receptor PD-1, can be expressed by various cell types in the tumour microenvironment. Here, the authors show that, in mouse models, the expression of PD-L1 from both cancerous and normal host immune cells is important for suppressing anti-tumour immune responses.