학술논문
A DNA methylation-based liquid biopsy for triple-negative breast cancer
Document Type
article
Author
Source
npj Precision Oncology, Vol 5, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2397-768X
Abstract
Abstract Here, we present a next-generation sequencing (NGS) methylation-based blood test called methylation DETEction of Circulating Tumour DNA (mDETECT) designed for the optimal detection and monitoring of metastatic triple-negative breast cancer (TNBC). Based on a highly multiplexed targeted sequencing approach, this assay incorporates features that offer superior performance and included 53 amplicons from 47 regions. Analysis of a previously characterised cohort of women with metastatic TNBC with limited quantities of plasma (