학술논문
Psychosocial Impact of Predictive Genetic Testing in Hereditary Heart Diseases: The PREDICT Study
Document Type
article
Author
Céline Bordet; Sandrine Brice; Carole Maupain; Estelle Gandjbakhch; Bertrand Isidor; Aurélien Palmyre; Alexandre Moerman; Annick Toutain; Linda Akloul; Anne-Claire Brehin; Caroline Sawka; Caroline Rooryck; Elise Schaefer; Karine Nguyen; Delphine Dupin Deguine; Cécile Rouzier; Gipsy Billy; Krystelle Séné; Isabelle Denjoy; Bruno Leheup; Marc Planes; Jean-Michael Mazzella; Stéphanie Staraci; Mélanie Hebert; Elsa Le Boette; Claire-Cécile Michon; Marie-Lise Babonneau; Angélique Curjol; Amine Bekhechi; Rafik Mansouri; Ibticem Raji; Jean-François Pruny; Véronique Fressart; Flavie Ader; Pascale Richard; Sophie Tezenas du Montcel; Marcela Gargiulo; Philippe Charron
Source
Journal of Clinical Medicine, Vol 9, Iss 5, p 1365 (2020)
Subject
Language
English
ISSN
2077-0383
Abstract
Predictive genetic testing (PGT) is offered to asymptomatic relatives at risk of hereditary heart disease, but the impact of result disclosure has been little studied. We evaluated the psychosocial impacts of PGT in hereditary heart disease, using self-report questionnaires (including the State-Trait Anxiety Inventory) in 517 adults, administered three times to the prospective cohort (PCo: n = 264) and once to the retrospective cohort (RCo: n = 253). The main motivations for undergoing PGT were “to remove doubt” and “for their children”. The level of anxiety increased between pre-test and result appointments (p p = 0.004 and p