학술논문
Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure
Document Type
article
Author
Concepcion Casado; Cristina Galvez; Maria Pernas; Laura Tarancon-Diez; Carmen Rodriguez; Víctor Sanchez-Merino; Mar Vera; Isabel Olivares; Rebeca De Pablo-Bernal; Alberto Merino-Mansilla; Jorge Del Romero; Ramon Lorenzo-Redondo; Ezequiel Ruiz-Mateos; María Salgado; Javier Martinez-Picado; Cecilio Lopez-Galindez
Source
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Elite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. We define exceptional EC (EEC) as HIV-1 subjects who maintain the EC characteristics without disease progression for more than 25 years. We analyzed three EEC, diagnosed between 1988 and 1992, who never showed signs of clinical disease progression in absence of any antiretroviral treatment. A comprehensive clinical, virological, and immunological study was performed. The individuals simultaneously exhibited ≥3 described host protective alleles, low levels of total HIV-1 DNA (0.50). Inflammation levels of EEC were similar to HIV-1 negative donors. Remarkably, they showed an exceptional lack of viral evolution and 8-fold lower genetic diversity (