학술논문
Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy
Document Type
article
Author
Jenniffer Linares; Anna Sallent-Aragay; Jordi Badia-Ramentol; Alba Recort-Bascuas; Ana Méndez; Noemí Manero-Rupérez; Daniele Lo Re; Elisa I. Rivas; Marc Guiu; Melissa Zwick; Mar Iglesias; Carolina Martinez-Ciarpaglini; Noelia Tarazona; Monica Varese; Xavier Hernando-Momblona; Adrià Cañellas-Socias; Mayra Orrillo; Marta Garrido; Nadia Saoudi; Elena Elez; Pilar Navarro; Josep Tabernero; Roger R. Gomis; Eduard Batlle; Jorge Pisonero; Andres Cervantes; Clara Montagut; Alexandre Calon
Source
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Standard platinum-based chemotherapy is the basis of treatment of many cancers, however a proportion of patients do not derive benefit. Here the authors show that the platinum-based drug oxaliplatin accumulates in cancer-associated fibroblasts, activating pathways associated with cancer progression and resistance to therapy.