학술논문
Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adultsResearch in context
Document Type
article
Author
Constanza Méndez; Hernán F. Peñaloza; Bárbara M. Schultz; Alejandro Piña-Iturbe; Mariana Ríos; Daniela Moreno-Tapia; Patricia Pereira-Sánchez; Diane Leighton; Claudia Orellana; Consuelo Covarrubias; Nicolás M.S. Gálvez; Jorge A. Soto; Luisa F. Duarte; Daniela Rivera-Pérez; Yaneisi Vázquez; Alex Cabrera; Sergio Bustos; Carolina Iturriaga; Marcela Urzua; María S. Navarrete; Álvaro Rojas; Rodrigo A. Fasce; Jorge Fernández; Judith Mora; Eugenio Ramírez; Aracelly Gaete-Argel; Mónica Acevedo; Fernando Valiente-Echeverría; Ricardo Soto-Rifo; Daniela Weiskopf; Alba Grifoni; Alessandro Sette; Gang Zeng; Weining Meng; José V. González-Aramundiz; Pablo A. González; Katia Abarca; Felipe Melo-González; Susan M. Bueno; Alexis M. Kalergis; María Soledad Navarrete; Constanza Del Río; Dinely Del Pino; Natalia Aguirre; Grecia Salinas; Franco Vega; Acsa Salgado; Thomas Quinteros; Marlene Ortiz; Marcela Puente; Alma Muñoz; Patricio Astudillo; Nicole Le Corre; Marcela Potin; Juan Catalán; Melan Peralta; Consuelo Zamanillo; Nicole Keller; Rocío Fernández; Sofía Aljaro; Sofía López; José Tomás González; Tania Weil; Luz Opazo; Paula Muñoz; Inés Estay; Miguel Cantillana; Liliana Carrera; Matías Masalleras; Paula Guzmán; Francisca Aguirre; Aarón Cortés; Luis Federico Bátiz; Javiera Pérez; Karen Apablaza; Lorena Yates; María de los Ángeles Valdés; Bernardita Hurtado; Veronique Venteneul; Constanza Astorga; Paula Muñoz-Venturelli; Pablo A. Vial; Andrea Schilling; Daniela Pavez; Inia Pérez; Amy Riviotta; Francisca González; Francisca Urrutia; Alejandra Del Río; Claudia Asenjo; Bárbara Vargas; Francisca Castro; Alejandra Acuña; Javiera Guzmán; Camila Astudillo; Carlos M. Pérez; Pilar Espinoza; Andrea Martínez; Marcela Arancibia; Harold Romero; Cecilia Bustamante; María Loreto Pérez; Natalia Uribe; Viviana Silva; Bernardita Morice; Marco Pérez; Marcela González; Werner Jensen; Claudia Pasten; M. Fernanda Aguilera; Nataly Martínez; Camila Molina; Sebastián Arrieta; Begoña López; Claudia Ortiz; Macarena Escobar; Camila Bustamante; Marcia Espinoza; Angela Pardo; Alison Carrasco; Miguel Montes; Macarena Saldías; Natalia Gutiérrez; Juliette Sánchez; Daniela Fuentes; Yolanda Calvo; Mariela Cepeda; Rosario Lemus; Muriel Suárez; Mercedes Armijo; Shirley Monsalves; Constance Marucich; Cecilia Cornejo; Ángela Acosta; Xaviera Prado; Francisca Yáñez; Marisol Barroeta; Claudia López; Paulina Donato; Martin Lasso; María Iturrieta; Juan Giraldo; Francisco Gutiérrez; María Acuña; Ada Cascone; Raymundo Rojas; Camila Sepúlveda; Mario Contreras; Yessica Campisto; Pablo González; Zoila Quizhpi; Mariella López; Vania Pizzeghello; Stephannie Silva
Source
EBioMedicine, Vol 91, Iss , Pp 104563- (2023)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: The Omicron variant has challenged the control of the COVID-19 pandemic due to its immuno-evasive properties. The administration of a booster dose of a SARS-CoV-2 vaccine showed positive effects in the immunogenicity against SARS-CoV-2, effect that is even enhanced after the administration of a second booster. Methods: During a phase-3 clinical trial, we evaluated the effect of a second booster of CoronaVac®, an inactivated vaccine administered 6 months after the first booster, in the neutralization of SARS-CoV-2 (n = 87). In parallel, cellular immunity (n = 45) was analyzed in stimulated peripheral mononuclear cells by flow cytometry and ELISPOT. Findings: Although a 2.5-fold increase in neutralization of the ancestral SARS-CoV-2 was observed after the second booster when compared with prior its administration (Geometric mean units p