학술논문
Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals
Document Type
article
Author
Anuradha Rajamanickam; Nathella Pavan Kumar; Arul Nancy Pandiaraj; Nandhini Selvaraj; Saravanan Munisankar; Rachel Mariam Renji; Vijayalakshmi Venkatramani; Manoj Murhekar; Jeromie Wesley Vivian Thangaraj; Muthusamy Santhosh Kumar; Chethrapilly Purushothaman Girish Kumar; Tarun Bhatnagar; Manickam Ponnaiah; Ramasamy Sabarinathan; Velusamy Saravanakumar; Subash Babu
Source
BMC Immunology, Vol 23, Iss 1, Pp 1-8 (2022)
Subject
Language
English
ISSN
1471-2172
Abstract
Abstract Background Plasmacytoid and myeloid dendritic cells play a vital role in the protection against viral infections. In COVID-19, there is an impairment of dendritic cell (DC) function and interferon secretion which has been correlated with disease severity. Results In this study, we described the frequency of DC subsets and the plasma levels of Type I (IFNα, IFNβ) and Type III Interferons (IFNλ1), IFNλ2) and IFNλ3) in seven groups of COVID-19 individuals, classified based on days since RT-PCR confirmation of SARS-CoV2 infection. Our data shows that the frequencies of pDC and mDC increase from Days 15–30 to Days 61–90 and plateau thereafter. Similarly, the levels of IFNα, IFNβ, IFNλ1, IFNλ2 and IFNλ3 increase from Days 15–30 to Days 61–90 and plateau thereafter. COVID-19 patients with severe disease exhibit diminished frequencies of pDC and mDC and decreased levels of IFNα, IFNβ, IFNλ1, IFNλ2 and IFNλ3. Finally, the percentages of DC subsets positively correlated with the levels of Type I and Type III IFNs. Conclusion Thus, our study provides evidence of restoration of homeostatic levels in DC subset frequencies and circulating levels of Type I and Type III IFNs in convalescent COVID-19 individuals.