학술논문
A Higher Concentration of Dialysate Magnesium to Reduce the Frequency of Muscle Cramps: A Narrative Review
Document Type
article
Author
Akshay Varghese; Eduardo Lacson; Jessica M. Sontrop; Rey R. Acedillo; Ahmed A. Al-Jaishi; Sierra Anderson; Amit Bagga; Katie L. Bain; Laura L. Bennett; Clara Bohm; Pierre A. Brown; Christopher T. Chan; Brenden Cote; Varun Dev; Bonnie Field; Claire Harris; Shasikara Kalatharan; Mercedeh Kiaii; Amber O. Molnar; Matthew J. Oliver; Malvinder S. Parmar; Melissa Schorr; Nikhil Shah; Samuel A. Silver; D. Michael Smith; Manish M. Sood; Irina St. Louis; Karthik K. Tennankore; Stephanie Thompson; Marcello Tonelli; Hans Vorster; Blair Waldvogel; James Zacharias; Amit X. Garg
Source
Canadian Journal of Kidney Health and Disease, Vol 7 (2020)
Subject
Language
English
ISSN
2054-3581
20543581
20543581
Abstract
Purpose of review: Strategies to mitigate muscle cramps are a top research priority for patients receiving hemodialysis. As hypomagnesemia is a possible risk factor for cramping, we reviewed the literature to better understand the physiology of cramping as well as the epidemiology of hypomagnesemia and muscle cramps. We also sought to review the evidence from interventional studies on the effect of oral and dialysate magnesium-based therapies on muscle cramps. Sources of information: Peer-reviewed articles. Methods: We searched for relevant articles in major bibliographic databases including MEDLINE and EMBASE. The methodological quality of interventional studies was assessed using a modified version of the Downs and Blacks criteria checklist. Key findings: The etiology of muscle cramps in patients receiving hemodialysis is poorly understood and there are no clear evidence-based prevention or treatment strategies. Several factors may play a role including a low concentration of serum magnesium. The prevalence of hypomagnesemia (concentration of