학술논문
Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
Document Type
article
Author
Source
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-8 (2024)
Subject
Language
English
ISSN
2051-5960
Abstract
Abstract DNA methylation analysis has become a powerful tool in neuropathology. Although DNA methylation-based classification usually shows high accuracy, certain samples cannot be classified and remain clinically challenging. We aimed to gain insight into these cases from a clinical perspective. To address, central nervous system (CNS) tumors were subjected to DNA methylation profiling and classified according to their calibrated score using the DKFZ brain tumor classifier (V11.4) as “≥ 0.84” (score ≥ 0.84), “0.3–0.84” (score 0.3–0.84), or “