학술논문
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
Document Type
article
Author
Kylie M. Quinn; Tabinda Hussain; Felix Kraus; Luke E. Formosa; Wai K. Lam; Michael J. Dagley; Eleanor C. Saunders; Lisa M. Assmus; Erica Wynne-Jones; Liyen Loh; Carolien E. van de Sandt; Lucy Cooper; Kim L. Good-Jacobson; Katherine Kedzierska; Laura K. Mackay; Malcolm J. McConville; Georg Ramm; Michael T. Ryan; Nicole L. La Gruta
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO.