학술논문
Effect of polypharmacy on plasma bepridil concentration in patients with heart failure: a multicenter retrospective study
Document Type
article
Author
Source
Journal of Pharmaceutical Health Care and Sciences, Vol 9, Iss 1, Pp 1-8 (2023)
Subject
Language
English
ISSN
2055-0294
Abstract
Abstract Background Polypharmacy, defined as the concurrent use of over six drugs, is common in the treatment of heart failure (HF); however, unpredictable drug interactions with bepridil may occur. In this study, we have elucidated the influence of polypharmacy on plasma bepridil concentrations in patients with HF. Methods We conducted a multicenter retrospective study involving 359 adult patients with HF who received oral bepridil. Because QT prolongation is an adverse effect following plasma bepridil concentrations ≥800 ng/mL, the risk factors for patients achieving these concentrations at steady state were elucidated via multivariate logistic regression. The correlation between bepridil dose and plasma concentration was examined. The effect of polypharmacy on the value of the concentration-to-dose (C/D) ratio was investigated. Results A significant relationship was observed between bepridil dose and plasma concentration (p