학술논문
Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2
Document Type
article
Author
Nobuyo Higashi-Kuwata; Kohei Tsuji; Hironori Hayashi; Haydar Bulut; Maki Kiso; Masaki Imai; Hiromi Ogata-Aoki; Takahiro Ishii; Takuya Kobayakawa; Kenta Nakano; Nobutoki Takamune; Naoki Kishimoto; Shin-ichiro Hattori; Debananda Das; Yukari Uemura; Yosuke Shimizu; Manabu Aoki; Kazuya Hasegawa; Satoshi Suzuki; Akie Nishiyama; Junji Saruwatari; Yukiko Shimizu; Yoshikazu Sukenaga; Yuki Takamatsu; Kiyoto Tsuchiya; Kenji Maeda; Kazuhisa Yoshimura; Shun Iida; Seiya Ozono; Tadaki Suzuki; Tadashi Okamura; Shogo Misumi; Yoshihiro Kawaoka; Hirokazu Tamamura; Hiroaki Mitsuya
Source
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Effective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and replication of various SARS-CoV-2 strains in cells and mice.