학술논문
Correlation between frailty and reduction in cortical thickness in patients with chronic obstructive pulmonary disease
Document Type
article
Author
Source
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Physical inactivity and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD) can lead to frailty and poor prognoses. However, little is known regarding the association between frailty and the human brain. We hypothesized that the brain structure could change according to frailty in patients with COPD and focused on cortical thickness. Cortical thickness measured by magnetic resonance imaging and frailty scores using the Kihon Checklist (KCL) were assessed in 40 patients with stable COPD and 20 healthy controls. Among the 34 regions assessed, multiple regions were thinner in patients with COPD than in healthy individuals (p