학술논문
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
Document Type
article
Author
Matthias Wielscher; Pooja R. Mandaviya; Brigitte Kuehnel; Roby Joehanes; Rima Mustafa; Oliver Robinson; Yan Zhang; Barbara Bodinier; Esther Walton; Pashupati P. Mishra; Pascal Schlosser; Rory Wilson; Pei-Chien Tsai; Saranya Palaniswamy; Riccardo E. Marioni; Giovanni Fiorito; Giovanni Cugliari; Ville Karhunen; Mohsen Ghanbari; Bruce M. Psaty; Marie Loh; Joshua C. Bis; Benjamin Lehne; Nona Sotoodehnia; Ian J. Deary; Marc Chadeau-Hyam; Jennifer A. Brody; Alexia Cardona; Elizabeth Selvin; Alicia K. Smith; Andrew H. Miller; Mylin A. Torres; Eirini Marouli; Xin Gào; Joyce B. J. van Meurs; Johanna Graf-Schindler; Wolfgang Rathmann; Wolfgang Koenig; Annette Peters; Wolfgang Weninger; Matthias Farlik; Tao Zhang; Wei Chen; Yujing Xia; Alexander Teumer; Matthias Nauck; Hans J. Grabe; Macus Doerr; Terho Lehtimäki; Weihua Guan; Lili Milani; Toshiko Tanaka; Krista Fisher; Lindsay L. Waite; Silva Kasela; Paolo Vineis; Niek Verweij; Pim van der Harst; Licia Iacoviello; Carlotta Sacerdote; Salvatore Panico; Vittorio Krogh; Rosario Tumino; Evangelia Tzala; Giuseppe Matullo; Mikko A. Hurme; Olli T. Raitakari; Elena Colicino; Andrea A. Baccarelli; Mika Kähönen; Karl-Heinz Herzig; Shengxu Li; BIOS consortium; Karen N. Conneely; Jaspal S. Kooner; Anna Köttgen; Bastiaan T. Heijmans; Panos Deloukas; Caroline Relton; Ken K. Ong; Jordana T. Bell; Eric Boerwinkle; Paul Elliott; Hermann Brenner; Marian Beekman; Daniel Levy; Melanie Waldenberger; John C. Chambers; Abbas Dehghan; Marjo-Riitta Järvelin
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find that these methylation changes are likely the consequence of inflammation and could contribute to disease.