학술논문
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes
Document Type
article
Author
Chloe Chong; Markus Müller; HuiSong Pak; Dermot Harnett; Florian Huber; Delphine Grun; Marion Leleu; Aymeric Auger; Marion Arnaud; Brian J. Stevenson; Justine Michaux; Ilija Bilic; Antje Hirsekorn; Lorenzo Calviello; Laia Simó-Riudalbas; Evarist Planet; Jan Lubiński; Marta Bryśkiewicz; Maciej Wiznerowicz; Ioannis Xenarios; Lin Zhang; Didier Trono; Alexandre Harari; Uwe Ohler; George Coukos; Michal Bassani-Sternberg
Source
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Non-canonical HLA-bound peptides from presumed non-coding regions are potential targets for cancer immunotherapy, but their discovery remains challenging. Here, the authors integrate exome sequencing, transcriptomics, ribosome profiling, and immunopeptidomics to identify tumor-specific non-canonical HLA-bound peptides.