학술논문
NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
In multiple myeloma, a 4;14 translocation induces overexpression of histone methyltransferase NSD2, resulting in expansion of H3K36me2 and shrinkage of H3K27me3 domains. Here the authors find that CTCF, H3K27ac and gene expression changes cluster within a subset of insulated domains implicating 3D chromosome organization as a key factor in the NSD2-mediated phenotype.