학술논문
Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells
Document Type
article
Author
Jagoda Siemaszko; Piotr Łacina; Donata Szymczak; Agnieszka Szeremet; Maciej Majcherek; Anna Czyż; Małgorzata Sobczyk-Kruszelnicka; Wojciech Fidyk; Iwona Solarska; Barbara Nasiłowska-Adamska; Patrycja Skowrońska; Maria Bieniaszewska; Agnieszka Tomaszewska; Grzegorz W. Basak; Sebastian Giebel; Tomasz Wróbel; Katarzyna Bogunia-Kubik
Source
Frontiers in Immunology, Vol 14 (2023)
Subject
Language
English
ISSN
1664-3224
Abstract
Transplantation of hematopoietic stem cells (HSCT) is a procedure commonly used in treatment of various haematological disorders which is associated with significantly improved survival rates. However, one of its drawbacks is the possibility of development of post-transplant complications, including acute and chronic graft-versus-host disease (GvHD) or CMV infection. Various studies suggested that NK cells and their receptors may affect the transplant outcome. In the present study, patients and donors were found to significantly differ in the distribution of the NKG2A rs7301582 genetic variants – recipients carried the C allele more often than their donors (0.975 vs 0.865, p