학술논문
Sub-genomic RNA Expression in SARS-CoV-2 B.1.411 and B.1.1.7 Infections in Sri Lanka
Document Type
article
Author
Source
International Journal of Infectious Diseases, Vol 116, Iss , Pp S24- (2022)
Subject
Language
English
ISSN
1201-9712
Abstract
Purpose: As experienced by many countries, Sri Lanka is currently experiencing a large COVID-19 outbreak, with over 90 cases/one million population. The previous outbreak, which was due to the B.1.411 virus (Sri Lankan lineage) resulted in a significantly fewer number of cases and deaths compared to the current outbreak caused by B.1.1.7. Therefore, we sought to explore if the differences in the transmission rates and higher mortality rates with the introduction of B.1.1.7 is due to an increased expression of sub-genomic RNA, which is an essential step in the virus life cycle. Methods & Materials: Sputum or nasopharyngeal samples of 472 patients with SARS-CoV-2 infection were included in the analysis. Samples with the cycle threshold