학술논문
Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life
Document Type
article
Author
D. Santos García; T. De Deus Fonticoba; J. M. Paz González; C. Cores Bartolomé; L. Valdés Aymerich; J. G. Muñoz Enríquez; E. Suárez; S. Jesús; M. Aguilar; P. Pastor; L. L. Planellas; M. Cosgaya; J. García Caldentey; N. Caballol; I. Legarda; J. Hernández Vara; I. Cabo; L. López Manzanares; I. González Aramburu; M. A. Ávila Rivera; M. J. Catalán; V. Nogueira; V. Puente; J. M. García Moreno; C. Borrué; B. Solano Vila; M. Álvarez Sauco; L. Vela; S. Escalante; E. Cubo; F. Carrillo Padilla; J. C. Martínez Castrillo; P. Sánchez Alonso; M. G. Alonso Losada; N. López Ariztegui; I. Gastón; J. Kulisevsky; M. Blázquez Estrada; M. Seijo; J. Rúiz Martínez; C. Valero; M. Kurtis; O. de Fábregues; J. González Ardura; C. Ordás; L. López Díaz; P. Mir; P. Martinez-Martin; COPPADIS Study Group
Source
Parkinson's Disease, Vol 2021 (2021)
Subject
Language
English
ISSN
2090-8083
2042-0080
2042-0080
Abstract
Introduction. In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient’s quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0–20; B: NMSS = 21–40; C: NMSS = 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p