학술논문
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
Document Type
article
Author
Mélissa Carbonneau; Laurence M. Gagné; Marie-Eve Lalonde; Marie-Anne Germain; Alena Motorina; Marie-Christine Guiot; Blandine Secco; Emma E. Vincent; Anthony Tumber; Laura Hulea; Jonathan Bergeman; Udo Oppermann; Russell G. Jones; Mathieu Laplante; Ivan Topisirovic; Kevin Petrecca; Marc-Étienne Huot; Frédérick A. Mallette
Source
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Oncogenic mutations of isocitrate dehydrogenases 1 and 2 result in the production of the oncometabolite R-2-hydroxyglutarate. Here the authors show that the oncometabolite promotes mTOR activation in a PTEN/PI3K-independent manner by regulating DEPTOR stability via inhibition of KDM4A activity.