학술논문
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes
Document Type
article
Author
Mikelly Santos Coutinho-da-Silva; Pedro Henrique Ferreira Sucupira; Kelly Alves Bicalho; Ana Carolina Campi-Azevedo; Joaquim Pedro Brito-de-Sousa; Vanessa Peruhype-Magalhães; Maria Rios; Andréa Teixeira-Carvalho; Jordana Grazziela Alves Coelho-dos-Reis; Lis Ribeiro do Valle Antonelli; Vitor Bortolo de Rezende; Fernanda Ludolf Ribeiro de Melo; Cristiana Couto Garcia; Jesuanne Carla Silva-Andrade; Ismael Artur da Costa-Rocha; Michele de Souza Bastos; Lucia Alves da Rocha; Valderjane Aprigio Silva; Ewerton da Silva Ferreira; Eveny Perlize Melo Marinho; Allyson Guimarães Costa; Matheus de Souza Gomes; Laurence Rodrigues Amaral; Erilene Cristina da Silva Furtado; Eliana Vieira Pinto da Silva; Bruna Alves Ramos; Éder Barros dos Santos; Maria Nazaré Oliveira Freitas; Pedro Fernando da Costa Vasconcelos; Olindo Assis Martins-Filho; Márcio Sobreira Silva Araújo; Milene Silveira Ferreira; Livia Carício Martins
Source
Frontiers in Immunology, Vol 13 (2022)
Subject
Language
English
ISSN
1664-3224
Abstract
A panoramic analysis of chemokines, pro-inflammatory/regulatory cytokines, and growth factors was performed in serum samples from patients with acute DENV infection (n=317) by a high-throughput microbeads array. Most soluble mediators analyzed were increased in DENV patients regardless of the DENV serotype. The substantial increase (≥10-fold) of CXCL10, IL-6, and IFN-γ, and decreased levels of PDGF (