학술논문
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.
Document Type
article
Author
Ying Wu; Lindsay L Waite; Anne U Jackson; Wayne H-H Sheu; Steven Buyske; Devin Absher; Donna K Arnett; Eric Boerwinkle; Lori L Bonnycastle; Cara L Carty; Iona Cheng; Barbara Cochran; Damien C Croteau-Chonka; Logan Dumitrescu; Charles B Eaton; Nora Franceschini; Xiuqing Guo; Brian E Henderson; Lucia A Hindorff; Eric Kim; Leena Kinnunen; Pirjo Komulainen; Wen-Jane Lee; Loic Le Marchand; Yi Lin; Jaana Lindström; Oddgeir Lingaas-Holmen; Sabrina L Mitchell; Narisu Narisu; Jennifer G Robinson; Fred Schumacher; Alena Stančáková; Jouko Sundvall; Yun-Ju Sung; Amy J Swift; Wen-Chang Wang; Lynne Wilkens; Tom Wilsgaard; Alicia M Young; Linda S Adair; Christie M Ballantyne; Petra Bůžková; Aravinda Chakravarti; Francis S Collins; David Duggan; Alan B Feranil; Low-Tone Ho; Yi-Jen Hung; Steven C Hunt; Kristian Hveem; Jyh-Ming J Juang; Antero Y Kesäniemi; Johanna Kuusisto; Markku Laakso; Timo A Lakka; I-Te Lee; Mark F Leppert; Tara C Matise; Leena Moilanen; Inger Njølstad; Ulrike Peters; Thomas Quertermous; Rainer Rauramaa; Jerome I Rotter; Jouko Saramies; Jaakko Tuomilehto; Matti Uusitupa; Tzung-Dau Wang; Michael Boehnke; Christopher A Haiman; Yii-Der I Chen; Charles Kooperberg; Themistocles L Assimes; Dana C Crawford; Chao A Hsiung; Kari E North; Karen L Mohlke
Source
PLoS Genetics, Vol 9, Iss 3, p e1003379 (2013)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Genome-wide association studies (GWAS) have identified ~100 loci associated with blood lipid levels, but much of the trait heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We conducted a trans-ethnic fine-mapping study at 18, 22, and 18 GWAS loci on the Metabochip for their association with triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), respectively, in individuals of African American (n = 6,832), East Asian (n = 9,449), and European (n = 10,829) ancestry. We aimed to identify the variants with strongest association at each locus, identify additional and population-specific signals, refine association signals, and assess the relative significance of previously described functional variants. Among the 58 loci, 33 exhibited evidence of association at P