학술논문

REstrictive versus StandarD FlUid Management in Mechanically Ventilated ChildrEn Admitted to PICU: study protocol for a pilot randomised controlled trial (REDUCE-1)
Document Type
article
Source
BMJ Open, Vol 13, Iss 11 (2023)
Subject
Medicine
Language
English
ISSN
2044-6055
Abstract
Introduction Intravenous fluid therapy is the most common intervention in critically ill children. There is an increasing body of evidence questioning the safety of high-volume intravenous fluid administration in these patients. To date, the optimal fluid management strategy remains unclear. We aimed to test the feasibility of a pragmatic randomised controlled trial comparing a restrictive with a standard (liberal) fluid management strategy in critically ill children.Methods and analysis Multicentre, binational pilot, randomised, controlled, open-label, pragmatic trial. Patients