학술논문
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding
Document Type
article
Author
Paul E Chappell; El Kahina Meziane; Michael Harrison; Łukasz Magiera; Clemens Hermann; Laura Mears; Antoni G Wrobel; Charlotte Durant; Lise Lotte Nielsen; Søren Buus; Nicola Ternette; William Mwangi; Colin Butter; Venugopal Nair; Trudy Ahyee; Richard Duggleby; Alejandro Madrigal; Pietro Roversi; Susan M Lea; Jim Kaufman
Source
eLife, Vol 4 (2015)
Subject
Language
English
ISSN
2050-084X
Abstract
Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely correlated in both chickens and humans. This relationship correlates with protective responses against infectious pathogens including Marek's disease virus leading to lethal tumours in chickens and human immunodeficiency virus infection progressing to AIDS in humans. We propose that differences in peptide binding repertoire define two groups of MHC class I molecules strategically evolved as generalists and specialists for different modes of pathogen resistance. We suggest that differences in cell surface expression level ensure the development of optimal peripheral T cell responses. The inverse relationship of peptide repertoire and expression is evidently a fundamental property of MHC molecules, with ramifications extending beyond immunology and medicine to evolutionary biology and conservation.