학술논문
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
Document Type
article
Author
Caterina Bartolacci; Cristina Andreani; Gonçalo Vale; Stefano Berto; Margherita Melegari; Anna Colleen Crouch; Dodge L. Baluya; George Kemble; Kurt Hodges; Jacqueline Starrett; Katerina Politi; Sandra L. Starnes; Daniele Lorenzini; Maria Gabriela Raso; Luisa M. Solis Soto; Carmen Behrens; Humam Kadara; Boning Gao; Ignacio I. Wistuba; John D. Minna; Jeffrey G. McDonald; Pier Paolo Scaglioni
Source
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Mutant KRAS (KM) is associated with poor prognosis in lung cancer and reported to promote lipid metabolism. Here, the authors show that fatty acid synthesis, which provides lipids to repair oxidized phospholipids through the FASN-Lands cycle axis, is a specific vulnerability for KM lung cancer.