학술논문
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
Document Type
article
Author
Giulia Della Chiara; Federica Gervasoni; Michaela Fakiola; Chiara Godano; Claudia D’Oria; Luca Azzolin; Raoul Jean Pierre Bonnal; Giulia Moreni; Lorenzo Drufuca; Grazisa Rossetti; Valeria Ranzani; Ramona Bason; Marco De Simone; Francesco Panariello; Ivan Ferrari; Tanya Fabbris; Francesca Zanconato; Mattia Forcato; Oriana Romano; Jimmy Caroli; Paola Gruarin; Maria Lucia Sarnicola; Michelangelo Cordenonsi; Alberto Bardelli; Nicola Zucchini; Andrea Pisani Ceretti; Nicolò Maria Mariani; Andrea Cassingena; Andrea Sartore-Bianchi; Giuseppe Testa; Luca Gianotti; Enrico Opocher; Federica Pisati; Claudio Tripodo; Giuseppe Macino; Salvatore Siena; Silvio Bicciato; Stefano Piccolo; Massimiliano Pagani
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.