학술논문
Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome
Document Type
article
Author
Etienne-Marie Jutant; Olivier Meyrignac; Antoine Beurnier; Xavier Jaïs; Tai Pham; Luc Morin; Athénaïs Boucly; Sophie Bulifon; Samy Figueiredo; Anatole Harrois; Mitja Jevnikar; Nicolas Noël; Jérémie Pichon; Anne Roche; Andrei Seferian; Samer Soliman; Jacques Duranteau; Laurent Becquemont; Xavier Monnet; Olivier Sitbon; Marie-France Bellin; Marc Humbert; Laurent Savale; David Montani
Source
ERJ Open Research, Vol 8, Iss 2 (2022)
Subject
Language
English
ISSN
2312-0541
23120541
23120541
Abstract
Rationale The characteristics of patients with respiratory complaints and/or lung radiologic abnormalities after hospitalisation for coronavirus disease 2019 (COVID-19) are unknown. The objectives were to determine their characteristics and the relationships between dyspnoea, radiologic abnormalities and functional impairment. Methods In the COMEBAC (Consultation Multi-Expertise de Bicêtre Après COVID-19) cohort study, 478 hospital survivors were evaluated by telephone 4 months after hospital discharge, and 177 who had been hospitalised in an intensive care unit (ICU) or presented relevant symptoms underwent an ambulatory evaluation. New-onset dyspnoea and cough were evaluated, and the results of pulmonary function tests and high-resolution computed tomography of the chest were collected. Results Among the 478 patients, 78 (16.3%) reported new-onset dyspnoea, and 23 (4.8%) new-onset cough. The patients with new-onset dyspnoea were younger (56.1±12.3 versus 61.9±16.6 years), had more severe COVID-19 (ICU admission 56.4% versus 24.5%) and more frequent pulmonary embolism (18.0% versus 6.8%) (all p≤0.001) than patients without dyspnoea. Among the patients reassessed at the ambulatory care visit, the prevalence of fibrotic lung lesions was 19.3%, with extent