학술논문
Identification of nine new susceptibility loci for endometrial cancer
Document Type
article
Author
Tracy A. O’Mara; Dylan M. Glubb; Frederic Amant; Daniela Annibali; Katie Ashton; John Attia; Paul L. Auer; Matthias W. Beckmann; Amanda Black; Manjeet K. Bolla; Hiltrud Brauch; Hermann Brenner; Louise Brinton; Daniel D. Buchanan; Barbara Burwinkel; Jenny Chang-Claude; Stephen J. Chanock; Chu Chen; Maxine M. Chen; Timothy H. T. Cheng; Christine L. Clarke; Mark Clendenning; Linda S. Cook; Fergus J. Couch; Angela Cox; Marta Crous-Bous; Kamila Czene; Felix Day; Joe Dennis; Jeroen Depreeuw; Jennifer Anne Doherty; Thilo Dörk; Sean C. Dowdy; Matthias Dürst; Arif B. Ekici; Peter A. Fasching; Brooke L. Fridley; Christine M. Friedenreich; Lin Fritschi; Jenny Fung; Montserrat García-Closas; Mia M. Gaudet; Graham G. Giles; Ellen L. Goode; Maggie Gorman; Christopher A. Haiman; Per Hall; Susan E. Hankison; Catherine S. Healey; Alexander Hein; Peter Hillemanns; Shirley Hodgson; Erling A. Hoivik; Elizabeth G. Holliday; John L. Hopper; David J. Hunter; Angela Jones; Camilla Krakstad; Vessela N. Kristensen; Diether Lambrechts; Loic Le Marchand; Xiaolin Liang; Annika Lindblom; Jolanta Lissowska; Jirong Long; Lingeng Lu; Anthony M. Magliocco; Lynn Martin; Mark McEvoy; Alfons Meindl; Kyriaki Michailidou; Roger L. Milne; Miriam Mints; Grant W. Montgomery; Rami Nassir; Håkan Olsson; Irene Orlow; Geoffrey Otton; Claire Palles; John R. B. Perry; Julian Peto; Loreall Pooler; Jennifer Prescott; Tony Proietto; Timothy R. Rebbeck; Harvey A. Risch; Peter A. W. Rogers; Matthias Rübner; Ingo Runnebaum; Carlotta Sacerdote; Gloria E. Sarto; Fredrick Schumacher; Rodney J. Scott; V. Wendy Setiawan; Mitul Shah; Xin Sheng; Xiao-Ou Shu; Melissa C. Southey; Anthony J. Swerdlow; Emma Tham; Jone Trovik; Constance Turman; Jonathan P. Tyrer; Celine Vachon; David VanDen Berg; Adriaan Vanderstichele; Zhaoming Wang; Penelope M. Webb; Nicolas Wentzensen; Henrica M. J. Werner; Stacey J. Winham; Alicja Wolk; Lucy Xia; Yong-Bing Xiang; Hannah P. Yang; Herbert Yu; Wei Zheng; Paul D. P. Pharoah; Alison M. Dunning; Peter Kraft; Immaculata De Vivo; Ian Tomlinson; Douglas F. Easton; Amanda B. Spurdle; Deborah J. Thompson
Source
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Endometrial cancer is the most common invasive gynaecological cancer in developed countries. Here a meta-analysis identifies an additional nine novel endometrial cancer risk loci and eQTL analysis reveals risk variants associate with reduced expression of negative regulators of oncogenic signal transduction proteins.