학술논문
T cell response against SARS-CoV-2 persists after one year in patients surviving severe COVID-19
Document Type
article
Author
Fabienne Venet; Morgane Gossez; Frank Bidar; Maxime Bodinier; Rémy Coudereau; Anne-Claire Lukaszewicz; Claire Tardiveau; Karen Brengel-Pesce; Valérie Cheynet; Marie-Angélique Cazalis; Rémi Pescarmona; Lorna Garnier; Marine Ortillon; Marielle Buisson; Maude Bouscambert-Duchamp; Florence Morfin-Sherpa; Jean-Sébastien Casalegno; Filippo Conti; Thomas Rimmelé; Laurent Argaud; Martin Cour; Mitra Saadatian-Elahi; Laetitia Henaff; Philippe Vanhems; Guillaume Monneret
Source
EBioMedicine, Vol 78, Iss , Pp 103967- (2022)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection is characterized by major immune dysfunctions. The capacity of these severe patients to mount a robust and persistent SARS-CoV-2 specific T cell response despite the presence of severe immune alterations during the ICU stay is unknown. Methods: Critically ill COVID-19 patients were sampled five times during the ICU stay and 9 and 13 months afterwards. Immune monitoring included counts of lymphocyte subpopulations, HLA-DR expression on monocytes, plasma IL-6 and IL-10 concentrations, anti-SARS-CoV-2 IgG levels and T cell proliferation in response to three SARS-CoV-2 antigens. Findings: Despite the presence of major lymphopenia and decreased monocyte HLA-DR expression during the ICU stay, convalescent critically ill COVID-19 patients consistently generated adaptive and humoral immune responses against SARS-CoV-2 maintained for more than one year after hospital discharge. Patients with long hospital stays presented with stronger anti-SARS-CoV-2 specific T cell response but no difference in anti-SARS-CoV2 IgG levels. Interpretation: Convalescent critically ill COVID-19 patients consistently generated a memory immune response against SARS-CoV-2 maintained for more than one year after hospital discharge. In recovered individuals, the intensity of SARS-CoV-2 specific T cell response was dependent on length of hospital stay. Funding: This observational study was supported by funds from the Hospices Civils de Lyon, Fondation HCL, Claude Bernard Lyon 1 University and Région Auvergne Rhône-Alpes and by partial funding by REACTing (Research and ACTion targeting emerging infectious diseases) INSERM, France and a donation from Fondation AnBer (http://fondationanber.fr/).