학술논문
Mechanical power thresholds during mechanical ventilation: An experimental study
Document Type
article
Author
Federica Romitti; Mattia Busana; Maria Michela Palumbo; Matteo Bonifazi; Lorenzo Giosa; Francesco Vassalli; Alessandro Gatta; Francesca Collino; Irene Steinberg; Simone Gattarello; Stefano Lazzari; Paola Palermo; Ahmed Nasr; Ann‐Kathrin Gersmann; Annika Richter; Peter Herrmann; Onnen Moerer; Leif Saager; Luigi Camporota; John J. Marini; Michael Quintel; Konrad Meissner; Luciano Gattinoni
Source
Physiological Reports, Vol 10, Iss 6, Pp n/a-n/a (2022)
Subject
Language
English
ISSN
2051-817X
Abstract
Abstract The extent of ventilator‐induced lung injury may be related to the intensity of mechanical ventilation––expressed as mechanical power. In the present study, we investigated whether there is a safe threshold, below which lung damage is absent. Three groups of six healthy pigs (29.5 ± 2.5 kg) were ventilated prone for 48 h at mechanical power of 3, 7, or 12 J/min. Strain never exceeded 1.0. PEEP was set at 4 cmH2O. Lung volumes were measured every 12 h; respiratory, hemodynamics, and gas exchange variables every 6. End‐experiment histological findings were compared with a control group of eight pigs which did not undergo mechanical ventilation. Functional residual capacity decreased by 10.4% ± 10.6% and 8.1% ± 12.1% in the 7 J and 12 J groups (p = 0.017, p