학술논문
LRP6 acts as a scaffold protein in cardiac gap junction assembly
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.