학술논문
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
Document Type
article
Author
Jordi Sintes; Maurizio Gentile; Shuling Zhang; Yolanda Garcia-Carmona; Giuliana Magri; Linda Cassis; Daniel Segura-Garzón; Alessandra Ciociola; Emilie K. Grasset; Sabrina Bascones; Laura Comerma; Marc Pybus; David Lligé; Irene Puga; Cindy Gutzeit; Bing He; Wendy DuBois; Marta Crespo; Julio Pascual; Anna Mensa; Juan Ignacio Aróstegui; Manel Juan; Jordi Yagüe; Sergi Serrano; Josep Lloreta; Eric Meffre; Michael Hahne; Charlotte Cunningham-Rundles; Beverly A. Mock; Andrea Cerutti
Source
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Subject
Language
English
ISSN
2041-1723
47467398
47467398
Abstract
Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation.